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质谱现场离子源电离机理的研究

批准号61501273 学科分类化学信息传感机理与传感器 ( F012302 )
项目负责人俞建成 负责人职称教授级高级工程师 依托单位宁波大学
资助金额23.00
万元
项目类别青年科学基金项目 研究期限2016 年 01 月 01 日 至
2018 年 12 月 31 日
中文主题词质谱;现场离子源;电离机理;亲和能;介质阻挡放电离子源
英文主题词Mass spectrometry;Ambient ionization source;Ionization mechanism;Affinity ;DBDI

摘要

中文摘要 现场离子源技术已成为当前质谱离子源研究中的前沿热点,具有灵敏度高、实时性好、支持质谱成像和样品预处理简单等优点,在生命科学、材料分析、公安刑侦、食品安全和环境监测等热点研究领域具有重要的应用价值。由于目前现场离子源的电离机理尚未明确,影响了它在这些领域中的广泛普及。本项目在现有离子源工作和当前电离理论模型的基础上,搭建现场离子源电离特性研究平台,研究离子、电子、激发态原子对目标化合物的电离机理,明确不同亲和能辅助电离气对电离目标化合物的作用关系,建立现场离子源的电离理论,解释现有理论中存在的问题,开展不同化合物的实验并验证理论,阐明电离机理。开展现场离子源对典型极性和非极性化合物的电离特性研究,探索电离方法和应用规律,以此丰富现场离子源的电离理论,揭示现场离子源的适用性。项目的研究成果将有助于推动现场离子源在快速检测分析领域的广泛应用,为发展现场快速质谱技术提供理论依据和技术支持。
英文摘要 Ambient ionization sources have become the hotspot of ion sources in current study mass spectrometry. It has the advantages of high sensitivity, supporting the mass spectrometry imaging and simple sample pretreatment and so on. It can be applied to the hot research field such as the life sciences, material analysis, criminal investigation, food safety analysis and environmental monitoring with great value. Currently , the ionization mechanism of the ambient ionization sources is not yet clear, thus the widespread popularity in the above applications is influenced. Based on the existing work and theoretical model in the ion source, the project establishes the platform of the ionization characteristics of the ambient ionization sources, studies the ionization mechanism of electron, positive ion and excited state atom for the target compounds, describes the ionization mechanism between different auxiliary gases and the target compounds. Ionization theory will be established and explain the existence the existing problems in the development of theory. Results of different compounds applied in experiments will verify the theory and clarify the ionization mechanism. Studies of the ionization characteristics of the ambient ionization sources for different typical polar and non-polar compounds, will explore the ionization methods and application law, enrich the theory of ionization field ion source, and reveal the applicability field ion source. Results of the project will promote the widespread use of the ambient ionization sources in the field of rapid detection and analysis and provide the theoretical basis and technical support for the development of the ambient mass spectrometry.
结题摘要

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