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癌症早期诊断标志物的实时分析

批准号20335040 学科分类毛细管电泳及电色谱 ( B050104 )
负责人汪尔康 职称研究员 单位名称中国科学院长春应用化学研究所
资助金额 120万元 项目类别 重点项目 起止年月 2004年01月01日 至 2007年12月31日
主题词 毛细管电泳;电化学发光;表面等离子体共振;癌症标志物;激光诱
附注说明 采用毛细管电泳(CE)电化学发光检测(ECL),表面等离子体共振(SPR)和激光诱导荧光技术和其他谱学和电化学技术方法,实现对肝癌和肺癌的标志物的实时、灵敏、特异性的在线检测,达到对肝癌和肺癌的预警和早期诊断。研究包括研制ECL仪和CE/ECL仪以及电化学发光探针用于分析标志物;设计和改造SPR仪器适于CE检测;发展CE/ECL技术和SPR技术,并与PCR、激光诱导荧光等技术结合,发展新的分离检测

成果

序号 课题 类型 参与人
0 当选日本分析化学会荣誉会员 奖励 汪尔康
1 中国科学院研究生院优秀教师奖 奖励 汪尔康
2 获中国科学院优秀研究生指导教师 奖励 汪尔康
3 电化学发光、毛细管电泳电化学发 奖励 汪尔康,董绍俊,杨秀荣,由天艳
4 生命分析化学 著作 汪尔康,陈义
5 Advances in Planar Lipid Bilay 著作 A. Ottova-Leltmannova Erkang W
6 毛细管电泳电化学发光联用技术用 会议 方兰云,尹学博,杨秀荣, 汪尔
7 Kinetic Study of Paracetamol o 会议 Jipei Yuan, Erkang Wang*
8 三联吡啶钌配合物掺杂硅薄膜修饰 会议 魏辉,汪尔康*
9 微流控芯片电化学发光检测的某些 会议 汪尔康
10 Some Aspects on Caillary Elect 会议 Erkang Wang
11 A study on the interaction bet 会议 Liangwei Du, Xiaohua Liu, Weim
12 Ionic liquid-assisted PDMS mic 会议 Yuanhong Xu, Hong Jiang, Erkan
13 Ru(bpy)32+固态电化学发光检测及 会议 汪尔康*
14 蛋白质和生物膜的相互作用研究 会议 汪尔康
15 Capillary Electrophoresis with 会议 Erkang Wang
16 Electron transfer in bio-compo 会议 孔继烈
17 Some Aspects of Nanoelectroche 会议 Erkang Wang
18 Electrochemiluminescence Senso 会议 Jing Li, Yuanhong Xu, Hui Wei,
19 Quantitative electrochemilumin 会议 Lanyun Fang, Hui Wei, Erkang W
20 Biological Synthesis of Calciu 会议 Liangwei Du, Erkang Wang*
21 离子液体和介孔材料固定吡啶钌 会议 李敬,黄明华,许元红,汪尔康*
22 某些电分析化学仪器的研发 会议 汪尔康
23 模拟生物膜体系电化学研究 会议 汪尔康
24 模拟生物膜对蛋白质及酶的相互作 会议 汪尔康
25 Direct Electrochemistry and El 会议 Gaiping Li, Liangwei Du, Hongj
26 A Study of Chlorpromazine with 会议 Lixue Zhang, Xiaohua Liu, Jiya
27 Characterization of procaine m 会议 Jipei Yuan, Erkang Wang*
28 毛细管电泳-Ru(bpy)32+电化学发 会议 袁吉培,金文睿,汪尔康*
29 A Water-Phase Synthesis of Sta 会议 Lixue Zhang, Xuping Sun, Erkan
30 Concentration and Time Dependa 会议 Xiaohua Liu, Haixin Bai, Weimi
31 一些电化学分析仪器的研制与开发 会议 汪尔康*
32 Bioelectrochemistry Study on M 会议 Erkang Wang
33 Simple, Sensitive and Label-fr 会议 Hui Wei, Bingling Li, Jing Li,
34 Analysis of quinolizidine alka 会议 Jianyuan Yin,Yuanhong Xu,Jin
35 Nanostructure at the Interface 会议 Erkang Wang
36 Synthesis of PtNPs/AQ/Ru(bpy)3 会议 Yan Du, Erkang Wang*
37 Electrochemical Detection of A 期刊 Yan Du, Jilin Yan, Junshan Liu
38 Analytical Applications of The 期刊 Xuebo Yin, Shaojun Dong, Erkan
39 Capillary electrophoresis and 期刊 Yan Du, Erkang Wang*
40 Controlled Protein Assembly on 期刊 Ying Liu, Li Mu, Baohong Liu,
41 A Novel Capacitive Immunosenso 期刊 Zan Liu, Song Huang, Dechen Ji
42 Stable Microstructured Network 期刊 Haiyun Qu, Haitao Wang, Yi Hua
43 Ionic Liquids as Selectors for 期刊 Tao Li, Bingling Li, Shaojun D
44 Highly Efficient Electrochemil 期刊 Yuanhong Xu, Ying Gao, Tao Li,
45 Determination of disopyramide 期刊 Lanyun Fang, Xue-bo Yin, Xiuhu
46 Label-free Immunosensors-princ 期刊 Ke Wang, Dechen Jiang, Baohong
47 Photoelectric Performance of B 期刊 Yidong Lu, Minjia Yuan, Yuan L
48 Dynamic Coating for Resolving 期刊 Jianzhen Kang, Jilin Yan, Jife
49 4-(Dimethylamino) Butyric Acid 期刊 Xuebo Yin, Bin Qi, Xuping Sun,
50 Controlled switchable surface 期刊 Ying Liu, Li Mu, Baohong Liu,
51 Manipulated Photocurrent Gener 期刊 Yidong Lu, Jingjing Xu, Yuan L
52 Electrochemiluminescence in Th 期刊 Jianzhen Kang, Hui Wei, Weiwei
53 Microchip Capillary Electropho 期刊 Yan Du, Hui Wei, Jianzhen Kang
54 Layer-By-Layer Assembled Multi 期刊 Lei Qian, Qiang Gao, Yonghai S
55 Sensitive Detection of Clozapi 期刊 Fei Huang, Song Qu, Song Zhang
56 Label Free Electrochemilumines 期刊 Hui Wei, Yan Du, Jianzhen Kang
57 Development of A Highly Enanti 期刊 Song Zhang, Jingjing Ding, Yin
58 Assembly of Prussian Blue onto 期刊 Lei Qian, Xiurong Yang*
59 Determination of Reserpine in 期刊 Weidong Cao, Xiurong Yang*
60 CE with Electrochemical Detect 期刊 Tao Li, Yan Du, Bingling Li, S
61 Adaptive Recognition of Small 期刊 Tao Li, Bingling Li and Shaoju
62 Electrochemistry and biosensin 期刊 Xin Xu, Bozhi Tian, Song Zhang
63 Luminescent Supramolecular Mic 期刊 Xuping Sun, Yan Du, Lixue Zhan
64 Capillary Electrophoresis Coup 期刊 Xuebo Yin, Erkang Wang*
65 Facile Separation And Determin 期刊 Jianyuan Yin, Weiwei Guo,Yan D
66 The Use of Capillary Electroph 期刊 Ying Gao, Qian Xiang, Yuanhong
67 Short-Capillary Electrophoresi 期刊 Xuebo Yin, Jianzhen Kang, Lany
68 Selective assembly of specific 期刊 Li Mu, Ying Liu, Song Zhang, B
69 Simultaneous Electrochemical a 期刊 Haibo Qiu, Xuebo Yin, Jilin Ya
70 Enantioselective sensing of ch 期刊 Xiuli Yin, Jingjing Ding, Song
71 One-Step Synthesis of Ru(2,2′ 期刊 Lei Qian, Xiurong Yang*
72 Didodecyldimethylammonium Brom 期刊 Lixue Zhang, Xuping Sun, Yongh
73 Simple and Sensitive Aptamer-b 期刊 Hui Wei, Bingling Li, Jing Li,
74 Microfluidic Chip with Electro 期刊 Xuebo Yin, Yan Du, Xiurong Yan
75 On-Chip Chiral Separation Base 期刊 Xuexiang Weng, Hongyan Bi, Bao
76 Interaction of anticancer drug 期刊 Nan Li, Ying Ma, Cheng Yang, L
77 Tris(2,2'-bipyridyl) Ruthenium 期刊 Wei Hui, Du Yan, Jianzhen Kang
78 Determining the Purity of Samp 期刊 Bin Chen, Xianrong Shen, Jilie
79 Electrochemical Impedance Dete 期刊 Aixue Li, Fan Yang, Ying Ma, X
80 Silver Nanoparticles Coated wi 期刊 Hui Wei, Jing Li, Yuling Wang,
81 The Effect of Template Phase o 期刊 Lixue Zhang, Peicai Li, Xiaohu
82 Submicrometre Scale Single-Cry 期刊 Hui Wei, Erkang Wang*
83 Preparation and Characterizati 期刊 Lei Qian, Xiurong Yang*
84 Chip Surface Charge Switch For 期刊 Xiaoqiang Cui, Fan Yang, Aixue
85 Interaction Between a-Actinin 期刊 Aixue Li, Fan Yang, Ying Ma, X
86 CE Coupling with End-Column El 期刊 Lanyun Fang, Jianzhen Kang, X
87 The Interaction of Recombinant 期刊 Aixue Li, Zhaozeng Sun, Ying M
88 Remarkably Enhanced Capacitanc 期刊 Xiaohua Zou, Song Zhang, Mianh
89 Preparation of Cobalt Hexacyan 期刊 Lei Qian, Xiurong Yang*
90 Promoted Electron Transfer of 期刊 Nan Li, Xiurong Yang*
91 Field-Amplified Sample Stackin 期刊 Yuanhong Xu, Ying Gao, Hui Wei
92 Electrochemiluminescence Quenc 期刊 Jianzhen Kang, Xuebo Yin, Xiur
93 Immunoassays Based on Microele 期刊 Mianhong Shi, Youyuan Peng, Ji
94 Conformational Changes of β-L 期刊 Xiaohua Liu, Li Shang, Xiue Ji
95 Fabrication Of a Poly(Dimethyl 期刊 Jilin Yan, Xiurong Yang, Erkan
96 Site-Specific Protein Immobili 期刊 Mianhong Shi, Youyuan Peng, Sh
97 Aptamer-Based Label-Free Metho 期刊 Tao Li, Bingling Li, Shaojun D
98 A Sensitive Impedance Immunose 期刊 Song Zhang, Fang Huang, Baohon
99 A Mediator-free Screen-printed 期刊 Mianhong Shi, Jingjing Xu, Son
100 An Electrochemical Study on th 期刊 Xiuhua Liu, Weimin Huang, Erka
101 A Smart Surface in a Microflui 期刊 Li Mu, Ying Liu, Shaoyu Cai,
102 Electrochemiluminescence Detec 期刊 Zhao Xiaocui, You Tianyan, Hai
103 Formation of [Ru(bpy)3]2+-Cont 期刊 Xuping Sun, Yan Du, Lixue Zhan
104 Direct electrochemical detecti 期刊 Yan Du, Jilin Yan, Weihong Zho
105 Multianalyte Immunoassay Based 期刊 Mianhong Shi, Youyuan Peng, Ji
106 Nucleobase-Metal Hybrid Materi 期刊 Hui Wei, Bingling Li, Yan Du,
107 Some Aspects in Capillary Elec 期刊 Xuebo Yin, Xiurong Yang, Erkan
108 Determination of Phenolic Comp 期刊 Youyuan Peng, Jiannong Ye, Jil
109 Determination of Ranitidine in 期刊 Ying Gao, Yiling Tian, Xiuhua
110 Biosynthesis of gold nanoparti 期刊 Liangwei Du, Hong Jiang, Xiaoh
111 Characterization of Prolidase 期刊 Jipei Yuan, Tao Li, Xue-Bo Yin
112 Electrochemiluminescence-based 期刊 Hui Wei, Erkang Wang*

摘要

结题摘要 采用毛细管电泳(CE)电化学发光检测(ECL),表面等离子体共振(SPR)和激光诱导荧光技术和其他谱学和电化学技术方法,实现对肝癌和肺癌的标志物的实时、灵敏、特异性的在线检测,达到对肝癌和肺癌的预警和早期诊断。研究包括研制ECL仪和CE/ECL仪以及电化学发光探针用于分析标志物;设计和改造SPR仪器适于CE检测;发展CE/ECL技术和SPR技术,并与PCR、激光诱导荧光等技术结合,发展新的分离检测肝癌和肺癌蛋白质和基因标志物的分析方法;研制快速、高灵敏度 、高选择性的多种技术结合的分析和微全分析系统;继而发展可检测多种蛋白和基因的芯片;把新的分析方法应用于临床病例的检测,建立临床物质成分与分析参数的数据库。本项研究对于快速分析癌症病人体液、组织液成分,建立相应的临床物质成分分析参数数据库,快速确定癌症标志物,以及对癌症预警和早期诊断,具有非常重要的临床应用价值。

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