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肿瘤预警标志物及相关生化信息的分析化学基础研究

批准号20335020 学科分类生化分析及生物传感 ( B0509 )
负责人姚守拙 职称教授 单位名称湖南师范大学
资助金额 120万元 项目类别 重点项目 起止年月 2004年01月01日 至 2007年12月31日
主题词 恶性肿瘤 标志物 早期诊断 新分析方法
附注说明 恶性肿瘤是严重危害人民生命健康的常见病、多发病。癌症的早期发现和诊断的重要手段之一就是对肿瘤标志物的高选择性、高灵敏、快速分析检测。本项目将以常见恶性肿瘤标志物为主要分析测试对象,以不同时期的癌症病人和乳腺中大量表达c-erbB-2的转基因鼠细胞或组织为研究对象,重点研究大肠癌、乳腺癌和肝癌等癌症的早期预警新分析方法, 同时探索新的肿瘤标志物。包括:(1) 细胞培养/免疫多参数传感监测新分析方法研究(2) 核酸和基因传感检测新方法研究(3) 纳米材料修饰增敏-声传感检测新方法研究(4) 微纳米级肿瘤组织宽频阻抗特性研究(5) 新型光谱电化学微探针用于肿瘤细胞或组织微区调制和检测研究

成果

序号 课题 类型 参与人
0 Highly luminescent CdTe quantu 期刊 Jifang Weng, Xingtao Song, Lia
1 Simultaneous determination of 期刊 Li Ding, Xubiao Luo, Fei Tang,
2 Study on the enhancement of Ru 期刊 Yingju Liu, Wen Pan, Qian Liu,
3 Simultaneous impedance measure 期刊 Qingji Xie*, Canhui Xiang, Xia
4 HER2介导乳腺癌细胞多药耐药的作 期刊 丁渭, 郑春艳, 贺智敏, 吕辉, 刘
5 Synthesis and characterization 期刊 Xinman Tu, Qingji Xie,* Zhao H
6 A new method for characterizin 期刊 Meiling Liu, Min Ye, Qin Yang,
7 Long-chained gemini surfactant 期刊 Qian Liu, Jinbin Yuan, Yanqing
8 Coupling fluorescence correlat 期刊 Chaoqing Dong, Rui Bi, Huifeng
9 Chemiluminescence detection in 期刊 Xiangyi Huang, Jicun Ren*
10 An amperometric hydrogen perox 期刊 Wenyan Tao, Dawei Pan, Yingju
11 电化学表面等离子体共振技术 期刊 王琼,唐浩*,谢青季*,姚守拙
12 Study on the interaction betwe 期刊 Shanchao Liu, Yingju Liu, Jia
13 Single molecule technology for 期刊 Kanglin Wang, Xi Qiu, Cunji Re
14 Determination of octopamine, s 期刊 Fei Tang, Liang Tao, Xubiao Lu
15 Survivin反义寡核苷酸对人肝癌细 期刊 张鸽文, 汤恢焕*, 王志明, 冯超,
16 Facile one-pot synthesis of hi 期刊 Huifeng Qian, Jicun Ren*
17 In situ FT-IR spectroelectroch 期刊 Mei Ling Wang, You Yu Zhang*,
18 反义抑制PTTG对胆管癌细胞VEGF表 期刊 陈鸰, 汤恢焕*, 冯超, 文言广,
19 人金属硫蛋白MT-2a的原核表达、 期刊 周敏, 杨芳, 贺智敏*, 刘孝荣,
20 Fluorescence quenching of bovi 期刊 Liang Tan, Lianying Liu, Qingj
21 Luminescent quantum dots: an a 期刊 Jifang Weng, Jicun Ren*
22 An EQCM study on the interacti 期刊 Zhijun Cao, Xueqin Jiang, Wenh
23 CdTe@Co(OH)2 (core/shell) nano 期刊 Liang Li, Huifeng Qian, Jicun
24 Quality control of medicinal h 期刊 Li Ding, Xu Biao Luo, Fei Tang
25 High quality and water-soluble 期刊 Huifeng Qian, Chaoqing Dong, C
26 Immobilization and electro-oxi 期刊 Hao Tang, Jinhua Chen*, Kunzai
27 Comparisons between capillary 期刊 Fuming Sang, Jicun Ren*
28 A novel amperometric sensor fo 期刊 Wen Pan, Xiaoli Chen, Manli Gu
29 Electrochemical oxidation of g 期刊 Hao Tang, Jinhua Chen*, Lihua
30 光谱法研究呋苄西林钠与牛血清白 期刊 杨朝霞, 张友玉*, 杨琴, 姚守拙
31 Characterization of solution-p 期刊 Chaoqing Dong, Pudun zhang, Cu
32 人HER2 胞外区基因重组及重组蛋 期刊 刘孝荣, 贺智敏*, 杨芳, 余艳辉,
33 醌型儿茶素单体EGCG和ECG对人肠 期刊 余艳辉, 丁仁圭, 张志伟, 欧阳咏
34 Simultaneous EQCM and fluoresc 期刊 Zhijun Cao, Qingji Xie*, Meng
35 Determination of difenidol hyd 期刊 Wen Pan, Yingju Liu, Yan Huang
36 Improved determination of 5-fl 期刊 Yanmin Yang, Qian Liu, Wenyan
37 Nonaqueous capillary electroph 期刊 Qian Liu, Yingju Liu, Yanqing
38 Study of fluorescence quenchin 期刊 Chaoqing Dong, Huifeng Qian, N
39 Monitoring of cell growth and 期刊 Manli Guo, Jinhua Chen, Xubin
40 QCM detection of adhesion, spr 期刊 Xue’en Jia, Zhiwei Zhang, Lia
41 Significant enhancement of the 期刊 Liang Li, Huifeng Qian, Nenghu
42 电化学石英晶体阻抗和FTIR-ATR研 期刊 杨琴, 刘美玲, 张友玉*, 谢青季
43 Single nonblinking CdTe quantu 期刊 Hua He, Huifeng Qian, Chaoqing
44 Investigation of double strand 期刊 Yingju Liu, Keqin Deng, Jia Li
45 Bcl-2/bax mRNA 在三氧化二砷体 期刊 周军,汤恢焕,马列,常实,王宪
46 Electrochemical quartz crystal 期刊 Qingji Xie*, Zhili Li, Chunyan
47 On-line chemiluminescence dete 期刊 Xiangyi Huang, Jicun Ren*
48 Molecularly imprinted thin fil 期刊 Zhaohui Zhang, Yumei Long, Lih
49 An electrochemical quartz crys 期刊 Hua He, Qingji Xie*, Shouzhuo
50 Electrodeposition of carbon na 期刊 Qingmei Zhou, Qingji Xie,* Yin
51 Enzymatically biocatalytic pre 期刊 Hao Tang*, Qiong Wang, Qingji
52 Study of polydimethylacrylamid 期刊 Peng Zhang, Jicun Ren*
53 Survivin反义寡核苷酸对人胆管癌 期刊 魏伟, 汤恢焕*, 冯超
54 A simple and sensitive method 期刊 Qian Liu, Yingju Liu, Manli Gu
55 肿瘤标志物与诊断技术(综述) 期刊 李嘉,刘善超,刘英菊,聂利华,
56 Characterization of quantum do 期刊 Xiangyi Huang, Jifang Weng, Ch
57 Simultaneous analysis of six a 期刊 Jinbin Yuan, Qian Liu, Weifeng
58 Sizes of water-soluble lumines 期刊 Pudun Zhang, Liang Li, Chaoqin
59 Rapid synthesis of highly lumi 期刊 Liang Li, Huifeng Qian, Jicun
60 Monitoring and estimation of t 期刊 Meiling Liu, Youyu Zhang*, Qin
61 Determination of mefenacet by 期刊 Shanchao Liu, Yingju Liu, Jia
62 荧光相关光谱及其在单分子检测中 期刊 张普敦,任吉存*
63 On-line investigation of laser 期刊 Chaoqing Dong, Cunji Ren*
64 Coupling chemiluminescence det 期刊 Qin Zhi, Chao Xie, Cunji Ren*
65 CuI-catalyzed Suzuki-Miyaura a 期刊 Jinheng Li*, Jilan Li, Deping
66 靶向抑制Survivin基因对肝细胞癌 期刊 张鸽文, 汤恢焕*, 王志明,李新营
67 DNA biosensor based on chitosa 期刊 Jia Li, Qian Liu, Yingju Liu,
68 葡萄糖、半乳糖和乙醇恒电流氧化 期刊 张丽军, 谢青季*, 姚守拙
69 荧光相关光谱单分子检测系统的研 期刊 张普敦,任吉存*
70 A sensitive and rapid immunoas 期刊 Jiaoning Wang, Jicun Ren*
71 Comparative study on the inter 期刊 Qian Liu, Jia Li, Wenyan Tao,
72 现场压电-红外反射光谱-电化学 期刊 张友玉*, 王美玲, 刘美玲, 杨琴,
73 毛细管电泳-激光诱导荧光鞘流检 期刊 陈林,任吉存*
74 Room-temperature ionic liquids 期刊 Qiong Wang , Hao Tang*, Qingji
75 Puri?cation of undiluted ionic 期刊 Fei Tang, Kangkang Wu, Li Ding
76 Electrochemical behavior of MC 期刊 Kun Chen, Jinhua Chen, Manli G
77 Improved electrochemical prope 期刊 Zhenfeng Li, Jinhua Chen, Wang
78 EQCM and fluoroeletrochemica I 期刊 Yuhua Su, Qingji Xie*, Zhijun
79 Genetic mutation analysis by c 期刊 Fuming Sang, Haixia Ren, Jicun
80 EQCM study of influences of he 期刊 Meng Li, Chunyan Deng, Xinman
81 Electrochemical piezoelectric 期刊 Liang Tan, Qingji Xie*, Shouz
82 Highly efficient size-dependen 期刊 Xingtao Song, Liang Li, Huifen
83 In situ monitoring Ni electrod 期刊 Youyu Zhang *, Meiling Liu, Me
84 One-pot aqueous synthesis of h 期刊 Huifeng Qian, Liang Li, Jicun
85 Cationic double-chained surfac 期刊 Yanqing Li, Qian Liu, Shouzhuo
86 Capillary electrophoresis of d 期刊 Fuming Sang, Jicun Ren*
87 New glucose biosensor based on 期刊 Chunyan Deng, Mingrui Li, Qing
88 Adsorption of bovine serum alb 期刊 Meiling Liu, Youyu Zhang*, Mei
89 A label-free electrochemical i 期刊 Hao Tang, Jinhua Chen, Lihua N
90 Simultaneous quartz crystal mi 期刊 Xueen Jia, Qingji Xie*, Youyu
91 A resonance energy transfer be 期刊 Xiangyi Huang, Liang Li, Huife
92 A study on tannic acid-doped p 期刊 Ling Jiang, Qingji Xie*, Zhili
93 Studies on electrochemical cop 期刊 Canhui Xiang, Qingji Xie*, Jim
94 Direct electrochemistry of glu 期刊 Chunyan Deng, Jinhua Chen*, Xi
95 Electrodeposited sol–gel-impr 期刊 Zhaohui Zhang, Lihua Nie, Shou
96 Identification and quantificat 期刊 Yining Zheng, Yang Sun, Jicun
97 Electrochemical study of breas 期刊 Jia Li, Xuanming Liu, Manli Gu
98 A sensitive amperometric broma 期刊 Zhenfeng Li, Jinhua Chen*, Daw
99 A new quantitative method for 期刊 Peng Zhang, Jicun Ren*
100 Study of fibrinogen adsorption 期刊 Qin Yang, Youyu Zhang*, Meilin
101 Aqueous synthesis of CdTe@FeOO 期刊 Liang Li, Jicun Ren*
102 Characterization and determina 期刊 Jinbin Yuan, Qian Liu, Guobing
103 水合高氯酸盐+有机溶剂体系中氢 期刊 彭谢兰, 谢青季*, 康青, 姚守拙
104 A simultaneous electrochemical 期刊 Hua He, Qingji Xie*, Youyu Zha
105 A novel method for quantificat 期刊 Peng Zhang, Jicun Ren*
106 Ultraviolet sealing and poly ( 期刊 Lin Chen, Jicun Ren*, Rui Bi,
107 人TNFAIP1基因克隆及其在常见细 期刊 杨利平,周爱东,张文峰,吴艳阳
108 A new immunoassay method by ca 期刊 Jiaoning Wang, Jicun Ren*
109 Electrochemical and spectro- e 期刊 Liang Tan, Qingji Xie*, Shouzh
110 Scanning electrochemical micro 期刊 Xinman Tu, Qingji Xie*, Canhui
111 镀金和碳纳米管修饰金电极上吸附 期刊 陈昕, 张漪丽, 苏育华, 孟文华,
112 To improve the quanti?cation s 期刊 Li Ding, Xubiao Luo, Fei-Li Ta
113 Enhanced adhesion/spreading an 期刊 Manli Guo, Jinhua Chen*, Yingj
114 Electrochemical determination 期刊 Liang Tan, Qingji Xie*, Shouzh
115 Microwave assisted aqueous syn 期刊 Huifeng Qian, Xing Qiu, Liang
116 GAS41 interacts with transcrip 期刊 Xiaofeng Ding,Changzheng Fan,
117 Molecularly imprinted solid-ph 期刊 Li Ding, Hui Li, Fei Tang, Sho
118 Cationic gemini surfactant as 期刊 Qian Liu, Yanqing Li, Fei Tang
119 An amperometric hydrogen rerox 期刊 Mingrui Li, Chunyan Deng, Chao

摘要

结题摘要 以结肠癌、乳腺癌、前列腺癌、肺癌等癌变标志物为主要分析测试对象,如癌胚抗原、甲胎蛋白及c-erbB-2、ras、p53 和人血清中循环DNA 等蛋白和基因类标志物,以不同组织病理学分型(高分化、中分化、低分化、未分化)的活检标本、病人血清和乳腺中大量表达c-erbB-2 的转基因鼠细胞或组织为研究对象,重点研究结肠癌、乳腺癌、前列腺癌、肺癌等癌症的早期预警新分析方法, 同时探索新的肿瘤标志物。包括:(1) 肿瘤标志物及相关生化信息的声、光、电传感检测新方法研究。(2) 毛细管电泳-激光荧光分析循环DNA,用于肿瘤预警。(3) 肿瘤标志物分子生物学方法研究。

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